A Genetic Screen for Genes Involved in Tissue Remodeling

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dc.contributorKnight, Jeff
dc.contributorHoyer-Leitzel, Alanna
dc.contributor.advisorWoodard, Craig
dc.contributor.authorWalchessen, Patricia
dc.date.accessioned2016-06-20T12:56:52Z
dc.date.available2016-06-20T12:56:52Z
dc.date.gradyear2016en_US
dc.date.issued2016-06-20
dc.descriptionUndergraduate honors thesis - Mount Holyoke College, 2016. Program in Biochemistry.en_US
dc.description.abstractTissue remodeling is vital to the health of any multicellular organism. Drosophila melanogaster, which undergoes tissue remodeling during metamorphosis, provides an excellent model to study this process due to highly conserved signaling pathways. During the period of metamorphosis, the larval fat body is remodeled from tightly connected sheets of polygonal cells into individual, free-floating spherical cells. Pupal lethal mutants were screened for abnormalities in the fat body as a way to identify genes involved in directing fat body remodeling. Fat-body morphology was characterized into specific categories: fat body with normal appearance, partially remodeled fat body, fat body that has not remodeled, fat body with abnormal cell appearance, and uncategorized. Four mutant lines with abnormal fat body morphology were identified are currently being characterizing with complementation tests and dissections at multiple developmental time points.en_US
dc.description.sponsorshipBiochemistryen_US
dc.identifier.urihttp://hdl.handle.net/10166/3891
dc.language.isoen_USen_US
dc.rights.restrictedrestricteden_US
dc.subjectDrosophilaen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectThird Chromosomeen_US
dc.subjectFat Bodyen_US
dc.subjectGeneticsen_US
dc.subjectTissue Remodelingen_US
dc.titleA Genetic Screen for Genes Involved in Tissue Remodelingen_US
dc.typeThesis
mhc.degreeUndergraduateen_US
mhc.institutionMount Holyoke College

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