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Examining Kinetic and Thermodynamic DNA Destabilization Caused by the cis-syn Thymine Dimer Lesion Using Small Molecule Probes
DNA alternates through continuous cycles of mutation and repair. When DNA is exposed to UV radiation, adjacent thymines within a strand covalently link together, forming a cyclobutane ring through saturation of the 5, 6 ...
Exploring DNA destabilization induced by the thymine dimer lesion using base
DNA frequently forms mutations due to endogenous or environmental conditions. During the Base Excision Repair pathway (BER), an enzyme removes damaged bases from DNA with a series of enzymatic steps. The thymine ...
Characterization of the cis-syn Thymine Dimer Lesion in Duplex DNA with Nuclear Magnetic Resonance
Ultraviolet irradiation from sun exposure can lead to permanent, covalent damage in DNA. The damaged sites can block the progression of polymerases, thereby preventing replication or transcription. The frequent occurrence ...