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Crosslinking the 3′ End of a VLAT to RNA Polymerase: A Method to Elucidate Forward Hyper-Translocation
On a typically strong E. coli promoter, as nascent RNA grows to 8-10 nt⎯accompanied by scrunching 6-8 bp of the enlarged transcription bubble⎯the initial DNA-RNAP contacts disrupt, upstream bubble rewinds, promoter escape ...
Evidence Supporting a Novel Mechanism of Abortive Initiation by E. coli RNA Polymerase
Transcription is one of the highly regulated steps in gene expression and comprises three phases – initiation, elongation and termination. In prokaryotes, the initiation phase is further divided into two steps: (1) promoter ...