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Investigating Octopaminergic/Tyraminergic Signaling and Tau Toxicity in a Drosophila Model of Alzheimer's Disease
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the presence of filamentous tau inclusions. Clinical studies have shown that the locus coeruleus (LC), the main source of noradrenaline in the brain ...
Coordination between Insulin Signaling and Ecdysone Signaling during Drosophila melanogaster Development
Insulin signaling is a remarkably conserved pathway that regulates nutrient storage and release in vertebrates and invertebrates. In Drosophila, growth and development are balanced through a mechanism involving insulin and ...
Insulin-like Receptor: The First Step into Drosophila melanogaster's Insulin-signaling Pathway
Many details about the mechanisms that regulate homeostasis still remain unknown, and metabolic diseases continue to cause a great deal of human suffering. In order to further our understanding of the mechanisms underlying ...