Mechanical characterization of modulus-tunable and surface-modifiable polydimethylsiloxane with AFM

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dc.contributorGomez, Maria
dc.contributor.advisorChen, Wei
dc.contributor.advisorAidala, Katherine
dc.contributor.authorTian, Ye
dc.date.accessioned2015-07-14T20:46:01Z
dc.date.available2015-07-14T20:46:01Z
dc.date.gradyear2015en_US
dc.date.issued2015-07-14
dc.description.abstractIn this study we investigated two polymeric reaction systems to fabricate stiffness-tunable and surface-modifiable polydimethylsiloxane (PDMS), a biomaterial commonly used in microfluidic devices for medical diagnostics and single-cell dynamics study. Using thiol-ene photochemistry, we gained insights about how different reaction variants, such as pre-polymer molecular weight, functional group ratio, and UV exposure time affect the stiffness of the cross-linked network. We compared different techniques for measuring stiffness and realized the advantage of atomic force microscopy (AFM) nano-indentation in characterizing the stiffness of soft, heterogeneous materials such as PDMS. We further applied what we learned from the thiol-ene system to platinum-catalyzed hydrosilylation reaction to study the effects of collagen adsorption on native as well as plasma-oxidized PDMS in terms of the dependence of the AFM-measured mechanical properties on surface chemistry.en_US
dc.description.sponsorshipChemistryen_US
dc.identifier.urihttp://hdl.handle.net/10166/3693
dc.language.isoen_USen_US
dc.rights.restrictedpublicen_US
dc.subjectAFMen_US
dc.subjectYoung's modulusen_US
dc.subjectPDMSen_US
dc.titleMechanical characterization of modulus-tunable and surface-modifiable polydimethylsiloxane with AFMen_US
dc.typeThesis
mhc.degreeUndergraduateen_US
mhc.institutionMount Holyoke College

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