Mechanical characterization of modulus-tunable and surface-modifiable polydimethylsiloxane with AFM
dc.contributor | Gomez, Maria | |
dc.contributor.advisor | Chen, Wei | |
dc.contributor.advisor | Aidala, Katherine | |
dc.contributor.author | Tian, Ye | |
dc.date.accessioned | 2015-07-14T20:46:01Z | |
dc.date.available | 2015-07-14T20:46:01Z | |
dc.date.gradyear | 2015 | en_US |
dc.date.issued | 2015-07-14 | |
dc.description.abstract | In this study we investigated two polymeric reaction systems to fabricate stiffness-tunable and surface-modifiable polydimethylsiloxane (PDMS), a biomaterial commonly used in microfluidic devices for medical diagnostics and single-cell dynamics study. Using thiol-ene photochemistry, we gained insights about how different reaction variants, such as pre-polymer molecular weight, functional group ratio, and UV exposure time affect the stiffness of the cross-linked network. We compared different techniques for measuring stiffness and realized the advantage of atomic force microscopy (AFM) nano-indentation in characterizing the stiffness of soft, heterogeneous materials such as PDMS. We further applied what we learned from the thiol-ene system to platinum-catalyzed hydrosilylation reaction to study the effects of collagen adsorption on native as well as plasma-oxidized PDMS in terms of the dependence of the AFM-measured mechanical properties on surface chemistry. | en_US |
dc.description.sponsorship | Chemistry | en_US |
dc.identifier.uri | http://hdl.handle.net/10166/3693 | |
dc.language.iso | en_US | en_US |
dc.rights.restricted | public | en_US |
dc.subject | AFM | en_US |
dc.subject | Young's modulus | en_US |
dc.subject | PDMS | en_US |
dc.title | Mechanical characterization of modulus-tunable and surface-modifiable polydimethylsiloxane with AFM | en_US |
dc.type | Thesis | |
mhc.degree | Undergraduate | en_US |
mhc.institution | Mount Holyoke College |
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