DEVELOPMENT OF CELLULOSE-BASED OXIDATION SENSITIVE DRUG DELIVERY VEHICLE
Date
2023-06-02
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Abstract
Biopolymers are an attractive avenue for drug delivery applications due to
their abundance, biocompatibility, sustainability, and flexible modification.
Cellulose-based materials are especially appealing, but their development is often
hampered by the poor solubility of their parent polymer. Hydrophobic groups can
be reversibly grafted onto a biopolymer to make oxidation-sensitive solubility switching materials.
While cellulose has a wide range of applications, from medical applications,
such as wound healing devices, to packaging materials, there have been fewer
studies on using modified cellulose as a targeted drug delivery vehicle. This
project expands on the current knowledge of cellulose modifications and
optimizes the creation of modified cellulose-based drug delivery vehicles.
Reactive oxidation species (ROS) sensitive groups were substituted on
cellulose to make hydrogen peroxide-responsive hydrophobic films and
microparticles. The modified cellulose was prepared through a solution-phase
reaction. The modified polymer can be fashioned into microparticles or films,
which were investigated to encapsulate hydrophobic cargo and release the
payload under oxidizing conditions. The new material may hold promise in drug eluting depot formations like stents, sutures, or beads.
The project successfully developed an oxidation-sensitive modified
cellulose drug delivery vehicle. Four ROS- sensitive groups (pinacol-modified
aryl-boronic ester, pinanediol-modified aryl-boronic ester, thioether, and
thioester) were grafted onto cellulose. Thioester-modified cellulose was oxidation
sensitive and could be formulated as microparticles. Nile red and rhodamine 6G
were encapsulated in thioester-modified cellulose to determine if the polymer
could hold therapeutics. SEM imaging revealed that the particles formed by the
nile red encapsulated polymer were independent and uniform with a diameter of
500nm. Due to time limitations, the unloaded polymer was not imaged but it can
be theorized that the diameter is less than 500 nm.
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Keywords
Drug Delivery, Cellulose