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dc.contributorFink, Rachel
dc.contributorBroaders, Kyle
dc.contributor.advisorWoodard, Craig
dc.contributor.authorLevy, Miriam
dc.date.accessioned2017-06-29T14:12:27Z
dc.date.available2017-06-29T14:12:27Z
dc.date.issued2017-06-29
dc.identifier.urihttp://hdl.handle.net/10166/4058
dc.description.abstractTissue remodeling is an essential process that occurs in multicellular organisms and is essential for the growth, development, and health of any organism. Drosophila melanogaster is an important organism for the study of this process as tissue remodeling is crucial for proper metamorphosis, during which the larval fat body remodels from a sheet of connected, polygonal cells into single, spherical cells which can then move throughout the body and head cavity of the fly. In this study, complementation tests were performed on lines of flies that each had a single mutation on the third chromosome that resulted in both abnormal fat body morphology and pharate adult lethality. The F1 progeny were scored for fat body morphology and adult lifespan post-eclosion in order to elucidate the relationship between the two phenotypes and better understand the role of potential novel genes. Abnormal fat body morphology was found to result in a reduced lifespan post-eclosion, where the degree of remodeling shows a slightly positive correlation with lifespan. In addition, I have begun to linkage map some of the mutations using pairs of dominant markers to identify the region of the third chromosome where each mutation is present.en_US
dc.description.sponsorshipBiological Sciencesen_US
dc.language.isoen_USen_US
dc.subjectGenetic Screenen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectTissue Remodelingen_US
dc.titleIdentifying Genes Involved in Larval Fat Body Remodeling in Drosophila melanogasteren_US
dc.typeThesis
dc.date.gradyear2017en_US
mhc.institutionMount Holyoke College
mhc.degreeUndergraduateen_US
dc.rights.restrictedpublicen_US


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