Sporadic Inclusion Body Myositis (s-IBM) is a degenerative muscle disorder. Symptoms include muscle weakness and loss of motor control. Abnormal accumulation of human Amyloid Precursor Protein (hAPP) and its proteolytic ...

In 1974, geneticist Bruce Wallace heard an address delivered by Hampton Carson describing three species of Drosophila that had independently adapted to live as obligate commensals of land crabs, spending at least the larval ...

Tissue remodeling is an important process by which cells dissociate and detach from one another. This phenomenon is involved in both healthy and disease driven functions in the human body including wound healing, and cancer ...

Matrix metalloproteinases are enzymes involved in important tissue remodeling mechanisms in many animal systems, including mammalian. They are required for scar resorption during wound healing, and are believed to also ...

Alzheimer’s disease (AD) and other tauopathies are characterized pathologically by neurofibrillary tangles (NFTs) composed of the microtubule-associated protein tau. These tangles correlate strongly with regional cell ...

Glial cells are one of the most abundant cell types in human brains, yet there is very little that we actually know about these cells. We do know that glial cells are important and vital regulators of the function of the ...

Filamentous inclusions of the protein tau in neuronal and glial cells characterize neurodegenerative tauopathies, such as Alzheimer’s disease (AD). The presence of these tau aggregates implies a dysfunction in the chaperone ...

Following the discovery of Insulin, it took the rest of the twentieth century to understand how this hormone regulates intracellular metabolism; however, understanding how insulin induces its profound effects on blood-glucose ...

Tissue remodeling is vital to the health of any multicellular organism. Drosophila melanogaster, which undergoes tissue remodeling during metamorphosis, provides an excellent model to study this process due to highly ...

Seizures are abnormal epochs of neuronal hyperexcitability. The lowcarbohydrate, high-fat ketogenic diet (KD) is an effective treatment for epilepsy in juveniles especially for drug-resistant seizures. KD produces ketone ...