Sporadic Inclusion Body Myositis (s-IBM) is a degenerative muscle disorder. Symptoms include muscle weakness and loss of motor control. Abnormal accumulation of human Amyloid Precursor Protein (hAPP) and its proteolytic ...

Filamentous inclusions of the protein tau in neuronal and glial cells characterize neurodegenerative tauopathies, such as Alzheimer’s disease (AD). The presence of these tau aggregates implies a dysfunction in the chaperone ...