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Sexually Dimorphic Heat Shock Protein Induction in a Drosophila melanogaster Model of Glial Tauopathy
Tauopathies are a broad class of neurodegenerative diseases characterized by aggregates of the microtubule-associated protein tau in both neurons and glia. Many tauopathies exhibit sexual dimorphism in their onset, ...
The role of Matrix metalloproteinase-2 in Drosophila melanogaster prepupal and pupal fat body autophagy
Autophagy is the mechanism by which an organism can dispose of parts of its cells. This mechanism plays a vital role in many human diseases such as cancer and neurodegenerative diseases, includings Alzheimer's disease ...
Regulation of Drosophila Fat Body Remodeling by Brain-secreted Drosophila Insulin-Like Peptides During Metamorphosis
Understanding the role of the brain in regulating peripheral metabolic activities may help unveil mechanisms underlying metabolic disorders. Drosophila melanogaster is a widely-used animal model for biological research, ...
Optimising a Method to Assess CNS Barrier Integrity and its Application to a Drosophila Model of Glial Tauopathy
The vertebrate blood brain barrier (BBB) allows for optimal functioning of billions of neurons and glia by regulating the diffusion and transport of toxins, inflammatory mediators, ions, and metabolites into and out of the ...